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Federal Reserve expected to raise US interest rates this week as all eyes on predictions for 2019

first_imgSunday 16 December 2018 6:25 pm whatsapp Thursday will also see UK retail statistics released by the Office for National Statistics. All eyes will be on the scale of the difference made by Black Friday last month.The annual weekend spending bonanza was a let-down for retailers this year, with footfall down 3.2 per cent as consumers continued the move to online shopping.Outspoken Sports Direct boss Mike Ashley said this November had been the “worst in living memory” last week. whatsapp The US Federal Reserve is this week widely expected to raise interest rates for the fourth time this year, with an anticipated range of between 2.25 and 2.50 per cent.But doubts have begun to emerge about Wednesday’s announcement among analysts, after comments from Federal Reserve chairman Jerome Powell that the level of interest rates is “just below neutral”. Tags: Bank of England Federal Reserve by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeBetterBe20 Stunning Female AthletesBetterBeUndoMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStoryUndoZen HeraldEllen Got A Little Too Personal With Blake Shelton, So He Said ThisZen HeraldUndoFinance Wealth PostTom Selleck’s Daughter Is Probably The Prettiest Woman To Ever ExistFinance Wealth PostUndoTotal PastJohn Wick Stuntman Reveals The Truth About Keanu ReevesTotal PastUndoMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailUndomoneycougar.comDiana’s Butler Reveals Why Harry Really Married Meghanmoneycougar.comUndoMedical MattersThis Picture Shows Who Prince Harry’s Father Really IsMedical MattersUndobonvoyaged.comTotal Jerks: These Stars Are Horrible People.bonvoyaged.comUndo Alex Daniel Federal Reserve expected to raise US interest rates this week as all eyes on predictions for 2019 Michael Hewson, chief market analyst at CMC Markets, said the comments meant the raise “is less of the done deal that it was two to three weeks ago”.The announcement will also contain projections for how much further the Federal Reserve will raise rates next year, “a key area of scrutiny” according to Hewson.All eyes will be on whether policymakers have lowered these expectations, which currently forecast three further rises in 2019 and one in 2020.Meanwhile, the Bank of England make similar rate decisions on Thursday. But with uncertainty over Brexit negotiations now looking set to continue well into the new year, analysts do not expect a change in policy.“The BoE simply cannot justify tightening its belt while the risks of a no-deal Brexit are there,” said Fawad Razaqzada, analyst at Forex. Share More From Our Partners Brave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgUK teen died on school trip after teachers allegedly refused her pleasnypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comWhy people are finding dryer sheets in their mailboxesnypost.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comKiller drone ‘hunted down a human target’ without being told tonypost.comMark Eaton, former NBA All-Star, dead at 64nypost.comSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.comKamala Harris keeps list of reporters who don’t ‘understand’ her: reportnypost.comlast_img read more

Tax cut promises ‘at odds’ with Tory manifesto, think tank says

first_img Experts have cast doubt on Boris Johnson’s promise to cut taxes (POOL/AFP via Getty Images) Adam Corlett, senior economic analyst at the Resolution Foundation, said: “Yes, the manifesto includes a national insurance cut worth up to £85 a year, at an overall cost of £2bn. The Resolution Foundation’s Corlett said the parties were not being upfront about their tax plans. “Britain seems to be heading for tax increases whoever wins the election, and politicians from all parties should be up front about why that change is needed,” he said. whatsapp whatsapp Matt Kilcoyne, deputy director of the Adam Smith Institute think tank, said it would not be accurate to characterise the scrapping of a planned tax cut as raising taxes. Yet he said the Tory manifesto showed a “lack of ambition” when it came to cutting taxes. The Resolution Foundation think tank today said the manifesto therefore “clearly shows net tax rises”. Read more: General Election: Boris Johnson sets out plan for first 100 days When asked about these criticisms on the campaign trail, Boris Johnson today said: “We are cutting taxes on national insurance contributions and business rates – I am certainly not aware of the data you describe.” Yet the Conservatives’ own manifesto costings document says there would be a net increase in tax revenue due to the scrapping of planned tax cuts laid out in the 2016 Finance Act. Boris Johnson’s claims that he would deliver a tax-cutting Budget in the first 100 days of a new government “are at odds with his party’s manifesto”, a think tank has said. “But this is dwarfed by the welcome £6bn revenue increase from cancelling planned corporation tax cuts.” center_img Paul Johnson, director of the Institute for Fiscal Studies, said: “Beyond a small reduction in NICs there are no tax cuts promised in the Conservative manifesto. The biggest announcement was in fact that a legislated cut to corporation tax would not happen.” More From Our Partners Colin Kaepernick to publish book on abolishing the policethegrio.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgMan on bail for murder arrested after pet tiger escapes Houston homethegrio.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgFort Bragg soldier accused of killing another servicewoman over exthegrio.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgLA news reporter doesn’t seem to recognize actor Mark Currythegrio.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.org Read more: General Election: Tory and Labour spending plans not credible, says IFS Thursday 5 December 2019 5:48 pm Ad Unmute by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily FunnyUndoNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableyUndozenherald.comDolly Finally Took Off Her Wig, Fans Gaspedzenherald.comUndoMisterStoryWoman files for divorce after seeing this photoMisterStoryUndoPast Factory4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!Past FactoryUndoNinjaJournalistMichael Jordan’s Divorce Settlement Has Finally Been Revealed.NinjaJournalistUndoBetterBe20 Stunning Female AthletesBetterBeUndobonvoyaged.comThese Celebs Are Complete Jerks In Real Life.bonvoyaged.comUndoPost FunRare Photos Show Us Who Meghan Markle Really IsPost FunUndo Share Tax cut promises ‘at odds’ with Tory manifesto, think tank says The Prime Minister last night laid out his priorities for government, saying chancellor Sajid Javid would hold a Budget that cut taxes for families in the months after the 12 December General Election. The Tory party plans to raise the national insurance payment threshold to £9,500, providing workers with a modest tax cut worth around £90 a year. He said the chancellor’s new commitment to balance the current budget means “it hard to see how there is fiscal space for any other significant tax cuts”. The IFS has previously said that the Tories would probably end up increasing both spending and taxes. Harry Robertson last_img read more

‘I cannot move this building’: Owner of historic boatworks digs in against Forest Service deadline

first_imgFederal Government | Southeast | State Government‘I cannot move this building’: Owner of historic boatworks digs in against Forest Service deadlineSeptember 4, 2020 by Jacob Resneck, CoastAlaska Share:Wolf Creek Boatworks owner Sam Romey says the belt driven shop machinery, shown in the 1940s, has not changed much in the last 80 years. (Photo courtesy of Sam Romey)The U.S. Forest Service has given the owner of a boat shop on Prince of Wales Island until mid-December to tear down the historic complex and leave.That’s in anticipation that the seven-acre parcel occupied by Wolf Creek Boatworks will be transferred to the Alaska Mental Health Trust.“I am now directing you to remove the boathouse and shop building, in addition to the (sic) those on the list of other structures and improvements shown in the removal plan,” Tongass Forest Supervisor Earl Stewart wrote on August 14. “I find that removal of the boathouse and shop building does not appreciably add to the removal work and restoration that you must complete by December 15, 2020.”Business owner Sam Romey says the agency’s demands are unrealistic.“I cannot move this building,” he said in a phone interview. “That’s the whole thing, and they know it. So I either destroy it and then they can say, ‘Oh, you destroyed it.’ Or I leave it and then they’ll half-ass it and let it fall in.”Wolf Creek Boatworks has been operating for about 80 years using power from a hydro turbine that’s a century old.Historians say it’s a key piece of the region’s maritime heritage, a holdover from the days of hand-built wooden fishing boats. The buildings were considered eligible to be included in the National Register of Historic Places in the 1980s but never listed.An aerial drone photo of Wolf Creek Boatworks on Prince of Wales Island in September 2019. (Photo courtesy of Sam Romey)But supporters say it’s no museum relic. The shop remains open for business, servicing boat owners on eastern Prince of Wales communities that would otherwise have to go to Ketchikan.The business’s Tongass National Forest lease expired in 2015. Romey says while he was working on his renewal, it was included as part of a massive transfer to the state’s mental health trust mandated by Congress.The Forest Service is supposed to be cataloging sites of historic value lost or destroyed in the transfer. The Forest Service also clarified that if the mental health trust inherits the boatworks buildings, it must manage them in accordance with state preservation laws.This summer, the Forest Service and trust authority agreed to a one-year extension on efforts to record and document historic sites, because of the COVID-19 pandemic.But Tongass Forest Supervisor Earl Stewart has not extended the time for Romey to vacate the property he’s managed for 25 years. The agency sent a letter on August 14 expanding the order to tear down the historic shop and boatworks by mid-December — or the owner can just walk away and let the mental health trust take possession of the historic site.Romey says he’s hired an attorney and plans to see the federal government in court.“They haven’t given me any choice in the matter,” Romey said. “It’s either I’m in a forced eviction with no compensation. Or I fight it. Well, I got 25 years into it. What’s another five years of fighting them?”The U.S. Forest Service declined an interview request but sent a short statement saying the agency had completed its federally-mandated review of the historic structures before ordering their removal.“We sent a letter to Mr. Romey after completing the process, amending the signed 2019 removal plan for his property, which has been in trespass since the expiration of his permit in 2015,” reads the statement sent by Tongass spokesman Paul Robbins Jr.The Forest Service solicited public comment this spring on what to do about the historic boatworks.It received more than two dozen letters of support for the longstanding business, one of the last of its kind in the region.Share this story:last_img read more

The Essential Movie Library #27: Singin’ in the Rain (1952)

first_imgFilmUncategorizedThe Essential Movie Library #27: Singin’ in the Rain (1952)A wry, inspired satire and Hollywood’s greatest musicalBy Steve Erickson – May 7, 20131180ShareEmailFacebookTwitterPinterestReddIt“Dignity,” intones Gene Kelly, a wicked gleam in his eye, “always dignity,” while whatever dignity Hollywood had is washed away in the movie’s artificial downpour. Feeling threatened by television and slightly irrelevant next to the explosion of world cinema, in the early 1950s Hollywood was caught up in a paroxysm of self-loathing as expressed by a rash of movies—The Bad and the Beautiful was the same year, two years after Sunset Boulevard—that ridiculed themselves.Produced by a Tin Pan Alley lyricist trying to get as many of his songs as possible into one picture (“All we knew,” screenwriter Betty Comden said later, “was that we had to work in a scene that had singing and raining”), this was, at best, a stealth masterpiece on first release. Within 20 years it would come to be regarded as the greatest American musical ever made, and nothing has changed that consensus since. The best measure of what’s irresistible about Singin’ in the Rain is that even without Kelly’s famous title number and Donald O’Connor’s demented “Make ’Em Laugh,” it would still be a wry and inspired satire; at the same time O’Connor’s preternatural optimism, former Miss Burbank Debbie Reynolds’s pluckiness in her first lead role, and co-director and star Kelly’s determined sense of joy suggested that Hollywood, having survived the transition from silence to sound—including the nerve-shredding screech of Lina Lamont, played by the wonderful Jean Hagen—would endure I Love Lucy and Kurosawa too. Read them all:The Essential Movie Library #26: HeatThe Essential Movie Library #25: L’AtalanteThe Essential Movie Library #24: SunriseThe Essential Movie Library #23: His Girl FridayThe Essential Movie Library #22: Black NarcissusThe Essential Movie Library #21: Blade RunnerThe Essential Movie Library #20: PersonaThe Essential Movie Library #19: The Shop Around the CornerThe Essential Movie Library #18: Lost HighwayThe Essential Movie Library #17: Tokyo StoryThe Essential Movie Library #16: 8 1/2The Essential Movie Library #15: City LightsThe Essential Movie Library #14: Seven SamuraiThe Essential Movie Library #13: Lawrence of ArabiaThe Essential Movie Library #12: Citizen KaneThe Essential Movie Library #11: Jules and JimThe Essential Movie Library #10: My Darling Clementine The Essential Movie Library #9: Double Indemnity The Essential Movie Library #8: That Obscure Object of Desire The Essential Movie Library #7: 2001: A Space Odyssey The Essential Movie Library #6: CasablancaThe Essential Movie Library #5: The Lady EveThe Essential Movie Library #4: The Third Man The Essential Movie Library #3: The Passion of Joan of Arc The Essential Movie Library #2: Vertigo The Essential Movie Library #1: The Godfather Trilogy TAGSEssential Movie LibraryGene KellyL.A CultureMovieMovie LibraryMusicalSingin’ in the RainPrevious articleEvent Watch: Wolfgang Puck + David Chang + Roy ChoiNext articleJames Beard Foundation Awards Narrowly Miss L.A. (Again)Steve Erickson RELATED ARTICLESMORE FROM AUTHORThe Holiday Season Officially Starts with These L.A. Tree Lighting EventsGorgeous Hotel Pools in L.A. Where You Can Cool Off Without Booking a RoomWhy You Should be Listening to Mexican-Born, L.A.-Based Rapper Niña Diozlast_img read more

Shangri La Comes to Los Angeles—Along With Many Other Islamic …

first_imgArtShangri La Comes to Los Angeles—Along With Many Other Islamic Art WorksThe Los Angeles Islam Arts Initiative sprawls across the city for four months; here are our can’t-miss eventsBy Theis Duelund – November 2, 2014594ShareEmailFacebookTwitterPinterestReddItFrom the Taj Mahal, built by a 17th century Mughal emperor to honor his wife, to Ms. Marvel, a comic book character created in part by Muslim author G. Willow Wilson, the art of Islam could fill a thousand museums. Since you probably can’t go to all of them, a new four-month program is bringing some of that art to you.The Los Angeles Islam Arts Initiative, which launched in early September, brings together some 30 cultural institutions to present art exhibitions, panels, discussions, and performances all over the city. The events and exhibitions feature traditional art from various Islamic regions alongside contemporary cinema and music. Our top picks:Doris Duke’s Shangri La: Architecture, Landscape, And Islamic ArtOver the course of her long life, tobacco heiress Doris Duke established an impressive collection of Islamic art works from interiors that evoke the grandeur of luxurious Bedouin tents to intricate and dazzling carpets. Much of it is now housed in Shangri La, her lavish five-acre estate located in Honolulu. Architectural documents, vintage photographs, and more than 60 objects from the collection including ceramics, textiles, jewelry, paintings, tile panels, and full-scale architectural elements are on display.DCA’s Los Angeles Municipal Art Gallery, 4800 Hollywood Blvd. October 26 – December 28.Histories Absolved: Revolutionary Cuban Poster Art and the Muslim InternationalThis exhibition presents an incredible collection of politically engaged posters created by members of the Organization of Solidarity with the Peoples of Africa, Asia, and Latin America (OSPAAAL), a Cuban human rights movement founded in 1966. Forget Shepard Fairy. These posters have ideological teeth and design chops that belie their age.Medina, 977 1/2 Chung King Road, Chinatown; November 8 – 14Drawing Out of Order: An Evening With Marjane Satrapi and Chris WareUSC’s Visions and Voices series hosts an evening with two comic book legends. Marjane Satrapi is the author of the groundbreaking 2000 graphic memoir Persepolis, which tells the story of her upbringing in Iran during the Islamic Revolution. Chris Ware is best known for intricately detailed graphic novels such as Jimmy Corrigan, the Smartest Kid on Earth (2000) and Building Stories (2012). Both authors have been lauded for redefining what a book can be and both are known to shoot from the hip. Expect and evening of candor, laughter, and insights about the graphic medium—and maybe about life.Bovard Auditorium, University Park Campus, USC; November 8, 7 – 8:30 p.m.Blue13 Dance Company PerformanceSanta Monica-based contemporary Indian dance company Blue13 will perform a new work commissioned for Grand Park’s annual Got Moves dance festival. During its public residency, which begins on November 10, the troupe will create and refine the piece. The process culminates in a celebration on the evening of Friday, November 14 with DJs from Discostan, a monthly dance party held at Footsie’s. Blue13 combines everything from ancient Indian dance to avant-garde moves. Mum’s the word on the specifics of their Grand Park piece, but dancers may wear “ghungroos” (ankle bells), which sounds like a good time.Grand Park, 200 N. Grand Ave., downtown; November 14, 8 p.m.Somewhere Between Here and Now: A Freewaves Video Screening and ConversationPresented by LA Freewaves, this event connects independent artists with audiences for an evening of video art and conversation. Featured artists include Basma Alsharif, Marwa Arsanios, Marwan Hamdan, Joe Namy, Christine Rebet, and Joanne Nucho. Curated by Suzy M. Halajian, founder of the mobile art collective Eighteen Thirty Collaborations In Los Angeles, Somewhere Between Here and Now offers encounters with artists whose disparate focii stretch from the nuances of Lebanese neighborhoods to a consideration of the space between turntablesHollywood Hookah Lounge, 6512 Hollywood Blvd., Hollywood; November 20, 8 p.m. TAGSChris WareLAIAIPersepolisPrevious articleWhere to Eat Now: Power-Ranking New L.A. Restaurants, Halloween EditionNext articleStep into Fall With a Pair of Bold Peep-Toe StilettosTheis Duelundlast_img read more

Miliband vows to end non-dom tax loophole

first_img Tags: NULL whatsapp Express KCS whatsapp Miliband vows to end non-dom tax loophole More From Our Partners Colin Kaepernick to publish book on abolishing the policethegrio.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgLA news reporter doesn’t seem to recognize actor Mark Currythegrio.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgPorsha Williams engaged to ex-husband of ‘RHOA’ co-star Falynn Guobadiathegrio.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgInstitutional Investors Turn To Options to Bet Against AMCvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.org Ed Miliband will today vow to abolish the non-domicile rule that allows many of the UK’s richest perm­anent residents to avoid paying tax in the UK on their global income. This could affect the likes of HSBC’s chief executive Stuart Gulliver, who can claim the status because he previously worked in Hong Kong. Share Tuesday 7 April 2015 9:12 pm Show Comments ▼last_img read more

News / Hapag-Lloyd to launch premium product as part of new five-year plan

first_img Hapag-Lloyd is to offer a choice between a standard or premium product across some of its service routes.The move follows an extensive market research survey by the carrier which revealed that more than 50% of respondents showed “a willingness to pay more” for a higher-quality offering.Hapag-Lloyd is convinced shippers actually mean what they say this time, despite the failure of previous premium products in the market, notably Maersk Line’s Daily Maersk offering.The Danish carrier launched its guaranteed space premium product in 2011, but four years on it had found that “customers were not willing to pay a higher price for better service”.Hapag-Lloyd’s Strategy 2023, unveiled at its first Capital Markets Day at its Hamburg head office yesterday, aims to set the carrier on a course for “quality, selective global growth and profitability”.Chief executive Rolf Habben Jansen said: “Having done two mergers in the last four years, one has to ask the question, OK, so what’s next?”And questioning the scale value for liner mergers, which he claimed “had diminished significantly”, he added: “Are there other ways to be successful, going forward?”He said: “We don’t see any further consolidation within the top six or seven carriers, but there could still be smaller players picked up by one or the other.“Size is not the name of the game anymore, but customer orientation. It is obvious that customers expect more reliable supply chains, so our industry needs to change and invest more.”Mr Habben Jansen outlined the three “overarching goals” of Strategy 2023: be profitable throughout the cycle; expand in key growth markets (taking its total global market share towards a target of 10% from the current 7%); and be number-one for quality, thereby focusing on having the best-paying cargo onboard its vessels. By Mike Wackett 22/11/2018 In order to achieve its profitability aspirations, “not only in the good years, but also in the bad”, Mr Habben Jansen revealed a new cost management programme that targeted an annual saving of between $350m and $400m.These would come from “network optimisation, terminal partnering and further improvements in procurement and container steering”, which includes reducing transhipment, empty equipment moves and feedering.Hapag-Lloyd also pledged more investment in digitalisation and automation, with a target of increasing its share of the online business via its web channel to 15% of its volumes by 2023, from the current 5% or so.center_img © Hieronymusukkel last_img read more

Rewriting reproduction: With stem cells and CRISPR, scientists breed mice with same-sex parents

first_img Tags CRISPRgeneticsresearch CRISPR cures inherited disorder in mice, paving way for genetic therapy before birth In the LabRewriting reproduction: With stem cells and CRISPR, scientists breed mice with same-sex parents For the first time, scientists said Thursday that they had bred mice with two genetic fathers, steering around biological hurdles that would otherwise prevent same-sex parents from having offspring.The researchers also bred mouse pups with two genetic mothers. Those pups matured into adults and had pups of their own, outpacing previous efforts to create so-called bimaternal mice.“This research shows us what’s possible,” Wei Li, a senior author of the study, said in a statement. Li conducted the work with colleagues at the Chinese Academy of Sciences.advertisement Of the 210 embryos created this way, 29 mice were born — just 14 percent. The mice appeared to be normal and even had regular gene expression patterns. By deleting those imprinted regions, the study indicated, the researchers effectively coaxed certain genes from one of the mothers to act as if they had come from a father in terms of their activity.“That was really sophisticated methodology,” Benvenisty said.The steps for breeding the bipaternal mice were even more complicated.Researchers again started with haploid embryonic stem cells, though this time containing paternal DNA (father No. 1), and deleted seven imprinted regions. They then injected the cells along with sperm from another mouse (father No. 2) into eggs that had had their own DNA removed. Finally, these embryos were transferred into surrogate mothers. (So while there was no maternal genetic information involved, female mice still played a role in forming the embryos and carrying them to term.)Only 12 bipaternal mice, out of 477 embryos, were born, and only two survived more than two days. Neither of those reached adulthood. The researchers also measured gene activity in the pups and found that some of the imprinted genes were not being expressed as if they had been inherited maternally. Andrew Joseph [email protected] A mouse pup that was born to two genetic fathers. Leyun Wang/Chinese Academy of Sciences About the Author Reprints Instead, outside researchers said, the study sheds light on the underlying biology that foils mammals from spinning off offspring without sexual reproduction — unlike some reptiles, fish, and amphibians, which are capable of asexual reproduction.“It really opens your imagination for what you can do in mammals,” said Dr. Nissim Benvenisty, the director of the Azrieli Center for Stem Cells and Genetic Research at the Hebrew University of Jerusalem, who was not involved in the study.At issue is “genomic imprinting,” an evolutionary feature found in mammals (and also flowering plants) that researchers believe blocks these species from producing progeny without both maternal and paternal DNA.In our genomes, there are two copies of each gene — one from mom, one from dad — and both get expressed to make us us. But there are some 100 genes where “imprints” stationed along the genome signal one copy to be active and one to be silent. Trending Now: Comparing the Covid-19 vaccines developed by Pfizer, Moderna, and Johnson & Johnson Exclusive analysis of biopharma, health policy, and the life sciences. @DrewQJoseph STAT+: The cells used to make the mouse embryos were profoundly manipulated. The vast majority of the embryos made did not result in births. And none of the bipaternal mouse pups — those with two genetic fathers — survived to adulthood.advertisement Please enter a valid email address. Leave this field empty if you’re human: “The other copy is there and it’s presented and there’s nothing wrong with the DNA sequence,” said Manus Patten, an evolutionary biologist at Georgetown University, who was not part of the new research. “It’s just turned off.”Mammals still need both sets, though, to have their full suite of genetic instructions. IGF2, for example, is a gene crucial for growth and development, but only the paternal copy is normally active. If we just inherited DNA maternally then, we wouldn’t grow or develop properly; that gene would simply remain off. On the flip side, there are a number of these genes for which we rely on our mothers.But scientists started challenging nature’s way a decade and a half ago. The trick was to cajole certain maternal genes to act like paternal genes in terms of their activity, or vice versa.A healthy adult bimaternal mouse (born to two mothers) with offspring of her own. Leyun Wang/Chinese Academy of SciencesIn 2004, a team of Japanese researchers for the first time created mice with two mothers by toying with imprint signals, though only one of the 10 mice born in that study — out of more than 400 embryos — grew to adulthood.To try to improve on past results, the researchers in the new study manipulated imprint instructions even more extensively.For the bimaternal mice, they started with embryonic stem cells containing a female mouse’s DNA (mother No. 1). These cells were like egg or sperm in that they were haploid — that is, they had half the number of chromosomes of other cells — but were unlike those sex cells in that they had no imprints ready to silence some genes. The stem cells had been grown in such a way that the DNA markers that normally tell certain genes to turn off had been removed.The scientists then went a step further and deleted three key imprinted regions from the cells’ genomes using the DNA editor CRISPR. Finally, they injected the cells into sex cells from another female mouse (mother No. 2), simulating something akin to fertilization. Newsletters Sign up for Morning Rounds Your daily dose of news in health and medicine. The results were instructive in their own way, outside experts said. The study offered additional evidence that imprinting is what prevents mammals from producing offspring without sexual reproduction. And it showed that even with the intensive cellular changes and genome editing, the research team still could not overcome imprinting and reach regular levels of gene expression.“We can’t yet make bipaternal mice that are viable,” said Marisa Bartolomei, a professor of cell and developmental biology at the University of Pennsylvania Perelman School of Medicine, who did not work on the new study. “It’s because the imprinting is still messed up in these mice.”Beyond the technical, legal, and ethical roadblocks that would prevent this type of research in people, experts pointed to another concern. If researchers created, say, a daughter from two mothers or two fathers, and if she were healthy and had children of her own, it is unknown what genetic ramifications might be passed onto the next generation.In this study, for example, the female mice born with two genetic mothers were later mated with regular males. They produced 22 pups from six litters. Thirteen grew into adults themselves, but nine died soon after birth. But for now, the notion of reproducing the experiment in humans is more a matter of science fiction than science. The new study, which appeared in Cell Stem Cell, does not indicate that researchers can now or could anytime soon pull off a similar feat with people. General Assignment Reporter Andrew covers a range of topics, from addiction to public health to genetics. Related: Privacy Policy By Andrew Joseph Oct. 11, 2018 Reprintslast_img read more

Labeling confusion led to wasted doses of Pfizer Covid-19 vaccine in first days of rollout

first_img About the Author Reprints Investigative Reporter Olivia is an investigative reporter at STAT, working to hold corporations and public bodies to account in their response to Covid-19. Pharmacists and executives at several health care systems said they didn’t feel they could risk using the extra dose, especially as Pfizer’s vaccine requires two doses, 21 days apart, to be effective. “We’re not fully confident of our future supply. Let’s say we use the six but we get fewer doses in the future, we might not have enough for the second dose,” said Findlay. “We need to be very cautious in managing that supply.”Across the country in Boston, Paul Biddinger, medical director for emergency preparedness at Mass General Brigham, said he’d heard of the extra doses from the British vaccine rollout earlier this month. Despite being prepared, his team still had to throw out the additional doses on the first day of distribution.advertisement With the Covid-19 vaccine in short supply, hospital pharmacists found themselves in the unexpected position of throwing away one in every six doses of the first Pfizer-BioNTech vaccines distributed this week in the United States.The confusion came over labeling: The vaccine comes in vials labeled as containing enough for five doses. But pharmacists discovered that, after thawing and mixing the contents with a diluent, each vial contained enough vaccine for six doses. Without explicit approval from the manufacturer, that final dose had to be discarded.“It was overtly clear early on there’s some extra volume,” said Russell Findlay, pharmacy manager at University of Utah Health. His colleagues called Pfizer on Tuesday to ask if they could use the extra dose, said Findlay, but the company wouldn’t give a definitive answer.advertisement In Texas, the extra doses were discarded on the first day of distribution but, by Wednesday morning, Houston Methodist Hospital chief executive Roberta Schwartz said her team heard from Pfizer that it was okay to use what’s in the vial.Finally, on Wednesday afternoon, the U.S. Food and Drug Administration updated its guidance, saying health care providers should feel free to use all the full doses within each vial. “At this time, given the public health emergency, FDA is advising that it is acceptable to use every full dose obtainable (the sixth, or possibly even a seventh) from each vial, pending resolution of the issue,” spokesperson Abigail Capobianco wrote in an email to STAT. But any spare half doses should not be combined with half doses from other vials to create a whole one, she added.But Pfizer was less definitive. Each vial contains enough vaccine for at least five doses, spokesperson Sharon Castillo said in an email to STAT, and each dose must contain 0.3ml. “The amount of vaccine remaining in the multidose vial after removal of 5 doses can vary, depending on the type of needles and syringes used,” she wrote.  ”At this time, we cannot provide a recommendation on the use of the remaining amount of vaccine from each vial. Vaccinators need to consult their institution’s policies for the use of multidose vials.”If the dosing confusion was raised in the U.K., the FDA and Pfizer ideally should have issued clearer instructions about using the extra dose before distribution began this week in the U.S., said John Grabenstein, adviser to the American Pharmacists Association. “In a situation of limited supply, any waste is unfortunate.”But all injectable medicines have overfill, he said, and the first stages of clinical practice normally raise small issues. “There’s a thousand matters to address in the first week. This one might only now rise to the level of getting checked out,” he said.It makes sense to have some left-over liquid in a vial, said Findlay. Slight variations in the syringes used by different health systems could have small effects on the size of each dose, and changes in air pressure at different altitudes could also affect the volume of vaccine in a vial.Even with the confusion over dosing, the first day of administering vaccines was a success, he said: “Yesterday was the best day of work I’ve ever had.” @OliviaGoldhill Olivia Goldhillcenter_img [email protected] By Olivia Goldhill Dec. 16, 2020 Reprints Tags CoronavirushospitalsVaccines HealthLabeling confusion led to wasted doses of Pfizer Covid-19 vaccine in first days of rollout Leon Neal/Getty Imageslast_img read more

Some restaurants add COVID-19 surcharge to the bill

first_imgCustomers agree.“I’d have to ask why…why it’s being added to the bill,” said Mark Allen, a Lee County resident. FGCU economist Victor Claar said businesses have to be careful with a Covid fee to avoid rubbing loyal customers the wrong way.But, if businesses are upfront about the additional charge, he believes most will be understanding. He even said if the charge comes as a surprise, it’s okay as a consumer, to speak up. “I think in most cases, there’s nothing wrong with asking an honest respectful question about whether or not the Covid fee can go away or be reduced,” said Claar.  RELATEDTOPICS Pandemic “lifeline” for restaurants nearing an end as winter approaches October 23, 2020 New waterside restaurant taking over empty building in Downtown Fort Myers March 19, 2021 Advertisement Advertisement“We’re taking a lot of steps that in the past we didn’t,” said Johnson. Johnson won’t be adding a COVID-19 fee to his checks, but he plans on raising prices on the menu. “I think that our consumers, especially here in Southwest Florida, are super sensitive to those types of fees and I don’t think that it’s good for business,” he said.  AdvertisementRecommended ArticlesBrie Larson Reportedly Replacing Robert Downey Jr. As The Face Of The MCURead more81 commentsGal Gadot Reportedly Being Recast As Wonder Woman For The FlashRead more29 comments LEE COUNTY, Fla. – As businesses across the country battle the coronavirus pandemic, some restaurant owners are adding something called a “COVID-19 surcharge” to the bill.It can come either in the form of a small percentage or a few extra bucks. Cleaning supplies, masks for staff, disposable menus and plastic to-go containers are costing restaurants more. Owner of Bubba’s Roadhouse and Saloon Jay Johnson said it boils down to an extra $2,000 a month.  Advertisement Local restaurants see lower turnout for Super Bowl celebrations February 8, 2021 AdvertisementTags: Covid surchargeRestaurants AdvertisementDC Young Fly knocks out heckler (video) – Rolling OutRead more6 comments’Mortal Kombat’ Exceeded Expectations Says WarnerMedia ExecutiveRead more2 commentsDo You Remember Bob’s Big Boy?Read more1 commentsKISS Front Man Paul Stanley Reveals This Is The End Of KISS As A Touring Band, For RealRead more1 comments Local restaurants, bars not ready to fully reopen after phase 3 announcement September 30, 2020last_img read more