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Vioxx trial winds down

first_img“Where we sit is, there is no question according to their own documents, that Vioxx causes heart attack and stroke,” Girardi told jurors. Girardi implored the jury to set an example for other drug companies by returning a verdict in favor of his client. “This case is far greater than Mr. Stewart Grossberg,” Girardi said. “What if one company out there based upon what you do says, `We’d like to think this through. We don’t want to hurt anyone?”‘ The drug maker faces more than 16,000 lawsuits involving Vioxx, which was pulled from the market in 2004 after a study found that it increased the risk of heart attacks. More than 2,000 Vioxx lawsuits filed in California have been consolidated in Los Angeles Superior Court by Judge Victoria G. Chaney. The outcome of the case is expected to serve as a guide for navigating through other California cases involving Vioxx. Grossberg took the stand briefly during the trial, which entered its fifth week Tuesday. “I used Vioxx for a number of years,” Grossberg told jurors, adding he only took the painkiller “as needed,” not every day. He detailed how he took the painkiller during a pain flare-up, suffering a heart attack a few weeks later that he said forced him to take a break from his job as a construction site supervisor. Doctors placed a stent in one of his arteries and he was eventually released from the hospital and put on medication to reduce his lipid levels. Stents are tiny metal scaffolds that prop up arteries to help blood flow. Two years later, Grossberg resumed taking Vioxx, but stopped in late August 2004 after hearing about problems with the painkiller. Three months later, he suffered chest pains and underwent a second stent placement. Medical experts who testified for Merck told jurors Grossberg had pre-existing health factors that led to his heart problems, including a history of heart disease in his family, elevated cholesterol, poor diet and exercise habits and years as a smoker.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! An elderly man who sued Merck & Co. had a long history of heart disease before he took the painkiller Vioxx, the drug he claims caused his heart attack, a lawyer argued Tuesday in closing arguments of a lawsuit against the pharmaceutical company. Merck attorney Tarek Ismail told jurors they should reject the claim that Vioxx caused Stewart Grossberg’s heart attack or accelerated his heart disease. He cited testimony from a pharmacist who reviewed Grossberg’s records that showed he had three prescriptions of 30 Vioxx pills each in the two years before his heart attack in September 2001. Ismail said Grossberg, at most, was a sporadic Vioxx user. “Mr. Grossberg had heart disease for years and that heart disease started years before he had his first Vioxx pill,” Ismail said. AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREFrumpy Middle-aged Mom: My realistic 2020 New Year’s resolutions. Some involve doughnuts.The case – the first Vioxx liability lawsuit to go to trial in California – was brought by Grossberg, 71, who began taking Vioxx in 1999 to manage joint pain in his knees, hands and elsewhere caused by osteoarthritis. Grossberg blames his heart attack on Vioxx and is seeking unspecified damages on grounds that the company was negligent and failed to warn users of the drug, among other allegations. Whitehouse Station, N.J.-based Merck & Co. claims Vioxx had no role in Grossberg’s heart ailments. Merck has won four cases and lost three. Another trial began this week in New Orleans. Earlier, Grossberg’s attorney Thomas Girardi argued that Merck knew the drug caused heightened risk of heart ailments but sought to mislead physicians and market Vioxx anyway. last_img

FA Cup victory shows Manchester City are a team to love, admire and fear

first_imgShare on LinkedIn Play Video Share on Facebook Sergio Agüero 0:48 Raheem Sterling Manchester City At which point something happened that looked like sport, which was by any definition sport but felt more like a statement of power. There had been a great deal of talk before this game about the meeting of the alphas, Troy versus Vinnie. Deeney himself had spoken about his own sporting dualism, the need to reach down and find that other person, Angry Troy.In the event there was barely any Troy at all – save the odd close-up of baffled Troy, exhausted Troy, Troy on the edge of someone else’s moment of history. Raheem Sterling was excellent throughout, as were Ilkay Gündoğan, De Bruyne and David Silva.As the goals began to mount, the Watford fans stood and clapped and roared their players on. They might as well have been shouting into the storm. This City team is an irresistible force, both of sport and of political will; beautifully constructed, massively over-resourced, equipped with its own gold-plated helicopter gunship of a management structure. This has been an act of will, a regime in action. But what is its end point? Whom does it glorify? Is it a surprise that the best manager in the world, with limitless backing, and a supremely well-informed executive around him, can win like this?By the end the Premier League’s 11th best team might as well have wandered in from a different level of professional sport altogether. Their record against City in the last three seasons reads: played seven, lost seven, combined score 30-4.But then, a club of Watford’s scale exists, essentially, as a feeder to City’s tier of football. Their wage bill is £200m a year less than the treble-winners. Watford sell to survive and prosper: City are restricted in what they can spend only by the rules of big football finance, and perhaps not even by that.The blue shirts danced their way to the final whistle, and then danced on after it. For now this is just a moment to glory in this team and these players. There has never been an FA Cup final quite like this. There has, it seems safe to say, never been an English team quite like this either. features Watford Pep Guardiola furious over financial fair play question after Man City’s treble triumph – video Sportblog Share on Twitter Pep Guardiola Topics Welcome to the new order. Domestic games: played 51, won 43. Domestic trophies: three out of three. Five-goal hauls: 11. Defeats since Christmas: one.Scan the history books, fan back to the big city clubs of Victorian times, linger on the red-shirted eras of the last 50 years. English domestic football has never seen anything quite like this single-season hit from Manchester City. It turns out we really do all live in a sky blue world now.City were not just brilliant at Wembley; they were disorienting. They were hypnotically good; good in a way that seems to pose wider questions of a sporting-existential nature about why, and how, anyone could have assembled a team this annihilatingly fine.At times it was thrilling. At others it was a little painful. With 50 minutes on the clock, as Watford’s players looked up from their pursuit of the sky blue shirts and contemplated, vaguely, some kind of rearguard from 2-0 down, some way of disrupting the sublime footballing machine pushing them to the edge of this game, they might just have glimpsed the Manchester City substitutes warming up.Sergio Agüero, Kevin De Bruyne and Leroy Sané can-canned along the touchline, watching idly, waiting for the call. It is easy to imagine the feelings of those Watford players as they went back to chasing and harrying, the deep lactic burn in the calves, the seconds starting to crawl and above all a kind of vertigo.This was a glorious day for Manchester City and a historic one for English football. City’s victory completed a first ever men’s domestic treble. And this astonishing team is a team to love, too, so wonderfully well-grooved, so brimful of invention and good habits.At times its key note is relentlessness, a group of players so in love with their own processes they simply don’t want to stop. Forty minutes on from that moment with the City subs, the game had indeed changed dramatically. Instead of 2-0 the score was 6-0. How do you stop a rising tide?The third goal was the most cruel. With De Bruyne now on the pitch, Watford basically fell apart. All that chasing: suddenly the yellow shirts were wide open on the halfway line, City on the ball with an embarrassment of green space to run into. Two passes took the ball to De Bruyne. A jink left Heurelho Gomes on the floor. It was hard to watch. Gomes is 38 now. He remains the same loose-limbed gangle of a goalkeeper, a bundle of boots and gloves whose every twitch seems to express some profound state of gloom. He turned to watch as De Bruyne clipped the ball into the back of the net and the day turned into something else.Wembley had been a lovely, soft, basking place before kick-off, the concourses thronging with blocks of yellow and patches of sky blue. The Watford fans were there hours before kick-off, packing out Wembley Way with flags and homemade signs, something about that connection to 1984, Elton, spangles and all that, ramping up the retro-magic shtick.As ever, the stadium itself was at its best for these occasions, split into seething, flag-decked halves, and exploding with pre-match tongues of fire from the pitch-side pyrotechnics. Kevin De Bruyne Share on Messenger Share on Pinterest FA Cup Share on WhatsApp Share via Email Reuse this contentlast_img read more

Gonorrhea other STIs on rise in Canada social media networks one possible

first_imgTORONTO – Rates of sexually transmitted infections are continuing to rise across Canada, say public health experts, who point to a number of possible reasons for the uptick in cases of gonorrhea, chlamydia and syphilis.“In general, all the sexually transmitted infections have been increasing in the last 20 years,” said Dr. Jason Wong, a physician epidemiologist at the BC Centre for Disease Control (BCCDC), who tracks cases of sexually transmitted infections, or STIs.The growth of dating apps is one suspected culprit, though no studies have been conducted to prove a link between online hookups and the spread of STIs, said Wong.“But logically, it’s easier to find sex and easier to find anonymous sex than it was before, which makes it harder for public health to track outbreaks when you don’t know who’s the contact for people that may have been exposed,” he said.“The technology certainly serves to be a quicker interface to connecting with sexual partners.”Wong also said more people appear to be having condomless sex, including those in the gay community, who once were at the vanguard of safe-sex campaigns in response to the HIV-AIDS epidemic.“But with HIV treatment being really so effective now that it’s essentially a chronic disease, the concern around contracting HIV has really decreased a lot and that potentially is diving the reduction in condom use,” he said.Last year, the province recorded 3,295 cases of gonorrhea, a dip from the roughly 3,700 a year earlier, but a major jump from 2012, when only 1,400 cases were reported.On the other side of the country, Nova Scotia has also noticed a steady rise in gonorrhea and chlamydia cases since 2016, primarily in the Halifax area, said Dr. Trevor Arnason, regional medical officer of health for the central zone, which includes the provincial capital.“In 2018, we are seeing slightly more than double the number of case reports than we’d expect based on the three previous years of data for the province,” he said. “Normally we would expect around 50 cases reported by the end of April, and there were over 100 reported cases across the province.”About 85 per cent of those were recorded in and around Halifax.There’s been a slow increase in cases of chlamydia in Nova Scotia since 2007, though no rapid jump in the number of infections as seen with gonorrhea, said Arnason, noting that syphilis cases have been declining since 2013, following an outbreak among men who have sex with men in 2009.Along with reduced condom use, Arnason said there’s a concern about the growing number of people engaging in sex with multiple partners, possibly facilitated by social networking sites and dating apps.“We know the vast majority of our cases are diagnosed in the under-30 age group and many of them are diagnosed at university or college sexual health clinics,” he said Monday from Halifax, which is home to several post-secondary institutions.With young girls and many boys in Canada being vaccinated against human papillomavirus — a major cause of cervical cancer — and changes to guidelines advising that lower-risk women be tested less often for that malignancy than previously recommended, there is likely less screening for gonorrhea and chlamydia, Arnason said. Such STI testing was often performed at the same time as a Pap smear.“Again, we don’t have any certainty, but there is concern that people are not getting tested as frequently and that is driving a long-term trend of increased transmission.”Nationally, statistics confirm bacterial STIs are on an upward trajectory in jurisdictions across the country. Alberta, for example, recorded 4,763 cases of gonorrhea in 2017, up from about 3,700 the previous year.In 2015, the latest year for which national figures are available, there were almost 116,500 cases of chlamydia, the most commonly reported STI in Canada, with females accounting for two-thirds of infections, says the Public Health Agency of Canada (PHAC). Between 2010 and 2015, chlamydia rates increased by almost 17 per cent.Gonorrhea is the second most commonly reported STI in the country. About 19,845 cases were recorded in 2015, a jump of more than 65 per cent from 2010. Males had higher rates than females, with the highest number of cases among those aged 15 to 29, PHAC says.From 2010 to 2015, the rate of infectious syphilis in Canada increased by almost 86 per cent. In 2015, a total of 3,321 cases were reported, with nearly 94 per cent occurring among males; those aged 20 to 39 had the highest rates and men who have sex with men were among those at most risk.While the three STIs can be successfully cured with antibiotics, untreated chlamydia and gonorrhea can lead to pelvic inflammatory disease in females, affecting fertility. Untreated, syphilis can cause damage to the brain, nerves, eyes, cardiovascular system, bones and joints. In extreme cases, it can be fatal.And when it comes to gonorrhea, Wong of the BCCDC said doctors are keeping an eye out for a rare strain of the bacterium that’s become resistant to one of the standard antibiotics long used to treat the disease, which turned up in a Quebec woman last year — the first such case in North America. About a half-dozen cases have been reported worldwide, notably in Japan and elsewhere in Asia.The Quebec woman had not travelled to Asia, but her boyfriend had been in Thailand and China and had unprotected sex in both countries, researchers reported.As a result, Wong said public health officials are closely monitoring gonorrhea cases “because we do have some concerns that our treatments are not going to be effective anymore.”Prevention is key, he said, stressing that condom use is among the best ways to protect against infection.“It’s not just the bugs we have to think about, it’s networks of people and how they connect with one another and thinking about what we can do to prevent people from getting these infections or getting complications,” he said.“But we’re also looking at what we can do on a population level that might suppress the potential that you would be exposed to these infections in the first place.”— Follow @SherylUbelacker on Twitter.last_img read more